Anti-depression pills, commonly known as antidepressants, are medications used to treat various forms of depression and related mental health conditions. Here’s an overview of the main types of antidepressants:
1. Selective Serotonin Reuptake Inhibitors (SSRIs)
These are among the most commonly prescribed antidepressants and work by increasing the level of serotonin in the brain. Examples include:
- Fluoxetine (Prozac)
- Sertraline (Zoloft)
- Escitalopram (Lexapro)
- Citalopram (Celexa)
2. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
SNRIs increase the levels of serotonin and norepinephrine in the brain. Common examples include:
- Venlafaxine (Effexor XR)
- Duloxetine (Cymbalta)
3. Tricyclic Antidepressants (TCAs)
These are older antidepressants that are less commonly prescribed now due to more side effects but can be effective for some individuals. Examples include:
- Amitriptyline
- Nortriptyline (Pamelor)
- Imipramine (Tofranil)
4. Monoamine Oxidase Inhibitors (MAOIs)
MAOIs are another older class of antidepressants that can be very effective but require dietary restrictions to avoid serious side effects. Examples include:
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
5. Atypical Antidepressants
These do not fit neatly into the other categories and have varied mechanisms of action. Examples include:
- Bupropion (Wellbutrin): Often used for depression and as a smoking cessation aid.
- Mirtazapine (Remeron): More often used when weight gain and sedation are desired effects.
Important Considerations
- Consult a Professional: It’s crucial to consult with a healthcare provider to determine the most appropriate medication based on individual symptoms, history, and any potential interactions with other medications.
- Side Effects: Each type of antidepressant can have different side effects, and it may take time to find the right one that works for an individual.
- Time to Effect: Antidepressants often take several weeks to show their full effects.
- Discontinuation: Stopping antidepressants suddenly can lead to withdrawal symptoms. A healthcare provider should guide any changes to medication.
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Citalopram
- $345.00 – $1,650.00
- Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor class. It is used to treat the major depressive disorder, obsessive-compulsive disorder, panic disorder, and social phobia. The antidepressant effects may take one to four weeks to occur. Wikipedia Molar mass: 324.392 g/mol CAS ID: 59729-33-8 Pronunciation: /saɪˈtæləˌpræm, sɪ-/; Metabolism: Liver (CYP3A4 and CYP2C19) Protein binding: <80% AHFS/Drugs.com: Monograph ATC code: N06AB04…
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Escitalopram
- $320.00 – $2,100.00
- Escitalopram, sold under the brand names Cipralex and Lexapro, among others, is an antidepressant of the selective serotonin reuptake inhibitor class. Escitalopram is mainly used to treat the major depressive disorder or generalized anxiety disorder. It is taken by mouth. Wikipedia Molar mass: 324.392 g/mol Formula: C20H21FN2O CAS ID: 128196-01-0 Pronunciation: /ˌɛsəˈtæləˌpræm/ pronunciation (help·info) Metabolism: Liver, specifically the enzymes CYP3A4 and CYP2C19 Protein binding: ~56% AHFS/Drugs.com: Monograph
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Fluoxetine
- $360.00 – $1,535.00
- Fluoxetine, sold under the brand names Prozac and Sarafem among others, is an antidepressant of the selective serotonin reuptake inhibitor class. It is used for the treatment of the major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Wikipedia IUPAC ID: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Molar mass: 309.33 g/mol Formula: C17H18F3NO CAS ID: 54910-89-3 Metabolism: Liver (mostly CYP2D6-mediated) Protein binding: 94–95% Soluble in: Water, Ethanol
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Fluvoxamine
- $370.00 – $2,200.00
- fluvoxamine 50 mg tablet Color: gold Shape: round Imprint: APO F50 This medicine is a gold, round, partially scored, film-coated, tablet imprinted with "APO" and "F50". Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor class. Wikipedia Formula: C15H21F3N2O2 Metabolism: Liver (via cytochrome P450 enzymes. Mostly via oxidative demethylation) Elimination half-life: 12–13 hours (single dose), 22 hours (repeated…
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MDMA 50mg
- $270.00 – $2,100.00
- 3,4-Methylenedioxymethamphetamine, commonly seen in tablet form and crystal form, is a potent empathogen–entactogen with stimulant properties primarily used for recreational purposes. The desired effects include altered sensations, increased energy, empathy, and pleasure. Wikipedia Formula: C₁₁H₁₅NO₂ ChEMBL Id: 43048 Molar mass: 193.25 g/mol IUPHAR ID: 4574 Other names: 3,4-MDMA; Ecstasy (E, X, XTC); Molly; Mandy; Pingers/Pingas Pronunciation: methylenedioxymethamphetamine: /ˌmɛθɪliːndaɪˈɒksi/; /ˌmɛθæmˈfɛtəmiːn/ Metabolism: Liver, CYP450 extensively involved, including CYP2D6
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Paroxetine
- $420.00 – $2,550.00
- Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor class. Wikipedia Molar mass: 329.37 g/mol Formula: C19H20FNO3 CAS ID: 61869-08-7 ChemSpider ID: 39888 Metabolism: Extensive, hepatic (mostly CYP2D6-mediated) Protein binding: 93–95% AHFS/Drugs.com: Monograph
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Sertraline
- $380.00 – $1,450.00
- Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor class. The efficacy of sertraline for depression is similar to that of other antidepressants, and the differences are mostly confined to side effects. Wikipedia Molar mass: 306.229 g/mol CAS ID: 79617-96-2 Boiling point: 907.7 °C Pronunciation: /ˈsɜːrtrəˌliːn/ Metabolism: Liver (primarily N-demethylation mainly by CYP2B6; also metabolism by CYP2C19, others) Protein binding: 98.5% AHFS/Drugs.com: Monograph
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